Incidental findings

Information

Every now and then a researcher may notice an abnormality on an MRI scan of a healthy participant or patient. Rarely (in less than 5% of the cases) it concerns an abnormality that requires further action to be taken.

Action is only to be taken if the abnormality is treatable and if the abnormality has negative consequences for the health of the individual. The medical ethical committee of the AMC deems it inappropriate to inform a participant or patient of an untreatable abnormality, unless the individual presents with symptoms related to the abnormality.

If you notice an abnormality on an MRI scan, but you are unsure whether it is a relevant finding or not, it is possible to request a radiologist of the AMC to examine your scans. Before contacting the radiology department, please consult your colleagues to make sure that you are looking at something serious, which may affect the participant’s health, and not an artefact or a white matter abnormality.

Procedure

Reporting an incidental finding goes according to the following procedure:

• Fill in the incidental findings form on www.spinozacentre.nl/wiki2.
• Send your structural scans in DICOM format to “AMC-classic”. On the 3T scanner you should provide a T1 and a Flair_Vista scan; on the 7T scanner you should provide a T1 scan and if possible a T2 scan. If it is not possible to provide a T2 scan, but it is possible to provide an EPI, please provide a single dynamic together with the T1 to “AMC-classic”.
• Request Paul Groot on Z0-182 to change the name to:

Name: 2000
Number: RESEARCH-2000
Acc#: Ayyyymmdd-hhmmss (so ‘year month day hour minute second’ of the moment of submission)

• Paul will send the images and information to impax, and will inform Tessa Oostendorp and the IT department about the incidental finding.
• Send an email to 3tmri@amc.uva.nl and Trijntje Sjoerdsma to report your incidental finding.
• Bring the form to Tessa Oostendorp in C1-206, t. 63602.
• Tessa will create a patient ID, process the request and send it to the IT department of the radiology department.
• The IT department will link the research number to the patient ID and transfer the images to a radiologist.
• The radiologist writes a report and sends an email to the responsible researcher with the outcome of the examination.
• The researcher then notifies the general practitioner of the participant about the outcome in case of a positive finding.

Text for in the information leaflet

There is a (very small) chance that the MRI scan turns up an unusual finding in your brain. In the unlikely event that an unusual finding is substantial a radiologist will take a closer look and, if he feels it is warranted, will inform your GP. We need your consent prior to the scan and we will ask for the name and address of your GP. Should you decline, you will not be able to participate in the MRI research.

Text for informed consent

I hereby agree that in case of incidental finding my general practitioner may be notified.